Phil Steele calls it "flight delay" when a heavily run-oriented team like 1990's Nebraska switches to a pass-heavy offensive scheme. He always strongly implied that it's harder to switch from running to passing than it is to switch from passing to running. He doesn't talk about it nearly as much as he used to, because nowadays there are so few classic option/power running teams so there also are very few schools switching up schemes in that drastic a fashion.
A genius coach could probably win regardless of scheme, but there aren't that many genius coaches. I think we'd be at a high risk of being a dumpster fire in the first year especially. Leave off QB for a second, and we're missing some other personnel -- no tight ends, no classic pass-blocking offensive tackles, and maybe not enough true WR's (though we'd be heavily overloaded at slot receiver). Also, we've gotten basically no practice at these kinds of schemes -- no zone blocking or zone reads, no shotgun snaps, no two-point OL stances set up to pass block. It takes practice to do those things well as a team, but we don't practice them. And learning to play well in pro style or spread passing schemes particularly takes practice for a QB -- if it didn't, there would be a lot more good true freshman QB's, instead of the phrase "true freshman QB" generally giving people hives (especially FSU fans this season).
Personally I love our offense for a number of reasons. Contrarian competitive advantage, giving us a unique identity nationally, and I just think it's fun to watch us elegantly brutalize opposing defenses.