It's easy to look at it either way. Personally, I look at it as the goal is to the win the regional, nothing less. To do that, you have to beat Vandy twice. As shaky as our pitching has been this year, that seems almost impossible to do without Hurter getting one of those games. So I would say just take your chances on Friday and hope to get to Vandy with Hurter on Saturday.
I will also note that while the ISU starter has a great ERA, in his last 5 games, he's given up 5, 2, 3, 4, and 2 runs to teams with presumably less firepower than us. If Archer/Maxwell/Bartnicki can keep them to 3-4 runs, I like my chances.