Well, Duke is a 1st quadrant team. Western Carolina, Pittsburgh, and Mercer are all 4th quadrant teams, but only because Q4 is defined as bottom half. Mercer is barely so at #165 out of the 299, Western Carolina is barely so at #183, Pittsburgh is #217. So while we need to go 7-0 against them for the visual of the record against Q4 teams, I would think a 6-1 wouldn't damage us in terms of the RPI calculations themselves.
A 1-2 @Duke and then a 6-1 against the rest would finish us at 37-17 and 19-11 in ACC play.
Lville I suspect will finish 2-1 (@ND), 2-1 (@UVA), 2-1 (FSU home) = 21-9.
UNCheat will probably finish 3-0, 1-2 = 19-11.
Miami will probably finish 2-1, 2-1 = 18-12.
Duke will probably finish 1-2, 1-2 = 15-15.
Note we control our own destiny in the Coastal - if we go 4-2 against Duke/Pitt, UNC because we own the tiebreaker would have to go 5-1. That's sweeping ND on the road and going 2-1 against NC State at home.
Miami owns the tiebreaker against us, so if we go 4-2, they need to finish 5-1 as well.
Duke would have to sweep GT and Miami to have a shot, which won't happen. But they could put some pressure on passing Miami.
So there is the key to me - if we go 4-2 against Pitt/Duke, that will really put the pressure on the rest of the Coastal. Anything better is gravy. And I don't think there is enough gravy to catch Louisville. They'd have to probably lose @UVA 1-2 and lose against FSU 1-2 somehow for us to finish in a tie and then use the tiebreaker.