Let's start no-huddle and then adjust at the LoS based on the Defensive alignment. If they're 9-in-the-box trying to stop the run, then I'd go stop-and-go with a fake quick out to a WR and go for a pass play, hoping their corner will bite on the pump and our receiver will jump him and either get open or a penalty call.
If they're playing their LB's and Safeties further off the LoS, then I'd look at where their line is stacking and maybe shift to an unbalanced set and go with a jet sweep to the strong side to see how they'll react for future reference. If they crash quickly from the outside, then we know they're looking at that as a key, so a counter option off of that, or play-action off of that to the B-Back could prove fruitful.