Yeah, I don't see it being dangerous. The whole reason teams like Alabama, LSU, tOSU, Texas, USCw, ND (and many more) have been so successful year after year is because they don't have second stringers, they've got 1A and 1B, and sometimes 1C players. Their depth is such that as the game approaches the late 3rd quarter and 4th quarter, they pull away because their players are better rested. Most decent teams can hang around for a while (not every team in every instance) because the 1st-1st talent gap isn't too big. But as the weaker team's 1's get tired, the stronger team begins to dominate because there's not a drop off in talent going to the back-ups. That's part of the game.
The Hurry-up Offense is more about not allowing the Defense to substitute so that the offense has an advantage in scheming, not anything to do with fatigue. For instance, if you have a run-stuffer at SDE that only plays 1st & 2nd downs but the other team forces you to use that DE to cover the TE coming off the line or a back in the Flats on 3rd down because you can't get him off the field, then the Offense has an advantage. The Offense is playing the same number of plays, at the same speed. They're just as tired.
As DCS said, there is zero evidence that the hurry-up offenses produces more injuries.
Besides, like I said in my previous post, I don't understand why they're trying to regulate this. Based on what was said in the article, only 1 play in each game reviewed was actually snapped prior to a 10-second run off. If that's the case, then why make a rule. I mean if you run 80 plays a game, and only 1 play would be legistlated, why? Additionally, if only 1.2% of the plays in a game are affected, how can anyone claim this is a safety issue?