midline is tough to run against a defense with a man head up the center. Considering, a typical midline is run right down the mid-line of the offense (meaning, right behind the center) towards the 3-technique side (outside shoulder of OG), you can't do that with a nose player.
You could run a variation and not block the DT playing on the OT, but that becomes a very tough read since the DT will be crashing down the line on both the give and the QB keep. Maybe that's a different play...kind of an inverted veer, but form under center.